Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Coupling of P2Y receptors to G proteins and other signaling pathways

L Erb, GA Weisman - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Abstract P2Y receptors are G protein‐coupled receptors (GPCRs) that are activated by
adenine and uridine nucleotides and nucleotide sugars. There are eight subtypes of P2Y …

Pathophysiology of astroglial purinergic signalling

H Franke, A Verkhratsky, G Burnstock, P Illes - Purinergic signalling, 2012 - Springer
Astrocytes are fundamental for central nervous system (CNS) physiology and are the fulcrum
of neurological diseases. Astroglial cells control development of the nervous system …

P2 receptors: intracellular signaling

L Erb, Z Liao, CI Seye, GA Weisman - Pflügers Archiv, 2006 - Springer
P2 receptors for extracellular nucleotides are divided into two categories: the ion channel
receptors (P2X) and the G-protein-coupled receptors (P2Y). For the P2X receptors, signal …

Targeting purinergic receptor P2Y2 prevents the growth of pancreatic ductal adenocarcinoma by inhibiting cancer cell glycolysis

LP Hu, XX Zhang, SH Jiang, LY Tao, Q Li, LL Zhu… - Clinical Cancer …, 2019 - AACR
Purpose: Extensive research has reported that the tumor microenvironment components
play crucial roles in tumor progression. Thus, blocking the supports of tumor …

Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection

C Séror, MT Melki, F Subra, SQ Raza, M Bras… - Journal of Experimental …, 2011 - rupress.org
Extracellular adenosine triphosphate (ATP) can activate purinergic receptors of the plasma
membrane and modulate multiple cellular functions. We report that ATP is released from HIV …

Not so strange bedfellows: G-protein-coupled receptors and Src family kinases

DK Luttrell, LM Luttrell - Oncogene, 2004 - nature.com
Src family nonreceptor tyrosine kinases are an integral component of the signal transduction
apparatus employed by growth factor receptor tyrosine kinases. As such, their role in cellular …

Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation

SK Mishra, N Braun, V Shukla, M Füllgrabe… - 2006 - journals.biologists.com
We have previously shown that the extracellular nucleoside triphosphate-hydrolyzing
enzyme NTPDase2 is highly expressed in situ by stem/progenitor cells of the two …

Nucleotide signaling in nervous system development

H Zimmermann - Pflügers Archiv, 2006 - Springer
The development of the nervous system requires complex series of cellular programming
and intercellular communication events that lead from the early neural induction to the …

Control of macrophage inflammation by P2Y purinergic receptors

D Klaver, M Thurnher - Cells, 2021 - mdpi.com
Macrophages comprise a phenotypically and functionally diverse group of hematopoietic
cells. Versatile macrophage subsets engage to ensure maintenance of tissue integrity. To …