Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …

It has become clear that platelets are not simply cell fragments that plug the leak in a
damaged blood vessel; they are, in fact, also key components in the innate immune system …

While platelet function has traditionally been described in the context of maintaining
vascular integrity, recent evidence suggests that platelets can modulate inflammation in a …

Platelets are non-nucleated cells that play central roles in the processes of hemostasis,
innate immunity, and inflammation; however, several reports show that these distinct …

Platelets are essential for physiological hemostasis and are central in pathological
thrombosis. These are their traditional and best known activities in health and disease. In …

Background: Atherosclerotic cardiovascular diseases are characterized by a dysregulated
inflammatory and thrombotic state, leading to devastating complications with increased …

Seven P2X receptor subunits have been cloned which form functional homo-and
heterotrimers. These are cation-selective channels, equally permeable to Na+ and K+ and …

Thrombocytopenia is commonly associated with sepsis and infections, which in turn are
characterized by a profound immune reaction to the invading pathogen. Platelets are one of …

Besides their undiscussed role in hemostasis and thrombosis, platelets are also key effector
cells capable of assisting and modulating inflammatory reactions and immune responses …

Circulating platelets have important functions in thrombosis and in modulating immune and
inflammatory responses. However, the role of platelets in innate immunity to bacterial …