Normal hearing depends on sound amplification within the mammalian cochlea. The
amplification, without which the auditory system is effectively deaf, can be traced to the …

Vestibular epithelia of the inner ear detect head motions over a wide range of amplitudes
and frequencies. In mammals, afferent nerve fibers from central and peripheral zones of …

The derivation of human inner ear tissue from pluripotent stem cells would enable in vitro
screening of drug candidates for the treatment of hearing and balance dysfunction and may …

The inner ear contains sensory epithelia that detect head movements, gravity and sound. It
is unclear how to develop these sensory epithelia from pluripotent stem cells, a process that …

Mechanosensitive sensory hair cells are the linchpin of our senses of hearing and balance.
The inability of the mammalian inner ear to regenerate lost hair cells is the major reason for …

Background Sensorineural hearing loss is the most common sensory deficit in the world,
with nearly 300 million affected individuals. The problem is multifactorial and can arise from …

The adult mammalian cochlea lacks regenerative capacity, which is the main reason for the
permanence of hearing loss. Vestibular organs, in contrast, replace a small number of lost …

Recruitment of endogenous progenitors is critical during tissue repair. The inner ear utricle
requires mechanosensory hair cells (HCs) to detect linear acceleration. After damage, non …

Vestibular sensation is essential for gaze stabilization, balance, and perception of gravity.
The vestibular receptors in mammals, Type I and Type II hair cells, are located in five small …

Afferent nerve fibers in the central zones of vestibular epithelia form calyceal endings
around type I hair cells and have phasic response properties that emphasize fast head …