TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Regulation of transposable elements by DNA modifications
Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …
elements (TEs), whose activity can have substantial deleterious effects on the host …
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
H3K27ac is well recognized as a marker for active enhancers and a great indicator of
enhancer activity. However, its functional impact on transcription has not been …
enhancer activity. However, its functional impact on transcription has not been …
Transcription factors drive Tet2-mediated enhancer demethylation to reprogram cell fate
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs) …
Mechanisms that regulate the activities of TET proteins
K Joshi, S Liu, P Breslin SJ, J Zhang - Cellular and Molecular Life Sciences, 2022 - Springer
The ten–eleven translocation (TET) family of dioxygenases consists of three members,
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET1, TET2, and TET3. All three TET enzymes have Fe+ 2 and α-ketoglutarate (α-KG) …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation
Bivalent genes are ready for activation upon the arrival of developmental cues. Here, we
report that BEND3 is a CpG island (CGI)–binding protein that is enriched at regulatory …
report that BEND3 is a CpG island (CGI)–binding protein that is enriched at regulatory …
A genome-scale map of DNA methylation turnover identifies site-specific dependencies of DNMT and TET activity
PA Ginno, D Gaidatzis, A Feldmann, L Hoerner… - Nature …, 2020 - nature.com
DNA methylation is considered a stable epigenetic mark, yet methylation patterns can vary
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
during differentiation and in diseases such as cancer. Local levels of DNA methylation result …
Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1
Chromatin inheritance entails de novo nucleosome assembly after DNA replication by
chromatin assembly factor-1 (CAF-1). Yet direct knowledge about CAF-1's histone binding …
chromatin assembly factor-1 (CAF-1). Yet direct knowledge about CAF-1's histone binding …
Targeting pericentric non-consecutive motifs for heterochromatin initiation
R Ma, Y Zhang, J Zhang, P Zhang, Z Liu, Y Fan… - Nature, 2024 - nature.com
Pericentric heterochromatin is a critical component of chromosomes marked by histone H3
K9 (H3K9) methylation,–. However, what recruits H3K9-specific histone methyltransferases …
K9 (H3K9) methylation,–. However, what recruits H3K9-specific histone methyltransferases …