Recent progress in cell culture and microfabrication technologies has contributed to the
development of cell‐based biosensors for the functional characterization and detection of …

While in vitro cell based systems have been an invaluable tool in biology, they often suffer
from a lack of physiological relevance. The discrepancy between the in vitro and in vivo …

Whole animal testing is an essential part in evaluating the toxicological and
pharmacological profiles of chemicals and pharmaceuticals, but these experiments are …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

One of the major branches of microfluidic development is cell engineering. A number of
devices for cell cultivation, lysis, single-cell analysis and cell-based toxicity tests have been …

In drug development, conventional preclinical and clinical testing stages rely on cell cultures
and animal experiments, but these methods may fall short of fully representing human …

Introduction: Accurate prediction of pharmacokinetic (PK) and toxicokinetics (TK) of drugs is
imperative for successful development of new pharmaceutics. Although conventional in vitro …

This article describes the development history of packed-bed bioreactors (PBRs) used for
the culture of mammalian cells. It further reviews the current applications of PBRs and …

Stem cells hold promise to revolutionize modern medicine by the development of new
therapies, disease models and drug screening systems. Standard cell culture systems have …

There is a need for microminiaturized cell-culture environments, ie NanoLiter BioReactors
(NBRs), for growing and maintaining populations of up to several hundred cultured …