“Stress” is 80 years old: From Hans Selye original paper in 1936 to recent advances in GI ulceration

S Szabo, M Yoshida, J Filakovszky… - Current pharmaceutical …, 2017 - ingentaconnect.com
The first scientific publication on 'general adaption syndrome', or as we know today 'biologic
stress' has been published in Nature in 1936 by the 29-year old Hans Selye. His results in …

Stable gastric pentadecapeptide BPC 157-NO-system relation

P Sikiric, S Seiwerth, R Rucman… - Current …, 2014 - ingentaconnect.com
We reviewed stable gastric pentadecapeptide BPC 157-NO-system-relation, its close
participation in Moncada's (maintained vascular integrity, platelets control) homeostatic …

The influence of a novel pentadecapeptide, BPC 157, on NG-nitro-L-arginine methylester and L-arginine effects on stomach mucosa integrity and blood pressure

P Sikirić, S Seiwerth, Ž Grabarević, R Ručman… - European journal of …, 1997 - Elsevier
The known effects of a novel stomach pentadecapeptide BPC157 (10 μg or 10 ng/kg),
namely its salutary activity against ethanol (96%, ig)-induced gastric lesions (simultaneously …

Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation

MJ Hsieh, HT Liu, CN Wang, HY Huang, Y Lin… - Journal of Molecular …, 2017 - Springer
BPC 157, a pentadecapeptide with extensive healing effects, has recently been suggested
to contribute to angiogenesis. However, the underlying mechanism is not yet clear. The …

Enhancement by PL 14736 of granulation and collagen organization in healing wounds and the potential role of egr-1 expression

VI Tkalčević, S Čužić, K Brajša, B Mildner… - European journal of …, 2007 - Elsevier
Apart from becaplermin (recombinant human platelet-derived growth factor homodimer of B
chains, PDGF-BB), for the treatment of lower extremity diabetic ulcers, few agents are …

Toxicity by NSAIDs. Counteraction by stable gastric pentadecapeptide BPC 157

P Sikiric, S Seiwerth, R Rucman… - Current …, 2013 - ingentaconnect.com
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, proven in
clinical trials to be both safe in inflammatory bowel disease (PL-10, PLD-116, PL 14736) and …

BPC 157 and standard angiogenic growth factors. Gastrointestinal tract healing, lessons from tendon, ligament, muscle and bone healing

S Seiwerth, R Rucman, B Turkovic… - Current …, 2018 - ingentaconnect.com
Commonly, the angiogenic growth factors signify healing. However, gastrointestinal
ulceration is still poorly understood particularly with respect to a general pharmacological …

Stable gastric pentadecapeptide BPC 157 may recover brain–gut axis and gut–brain axis function

P Sikiric, S Gojkovic, I Krezic, IM Smoday, L Kalogjera… - Pharmaceuticals, 2023 - mdpi.com
Conceptually, a wide beneficial effect, both peripherally and centrally, might have been
essential for the harmony of brain–gut and gut–brain axes' function. Seen from the original …

Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract

P Sikiric, S Seiwerth, R Rucman… - Current …, 2011 - ingentaconnect.com
Stable gastric pentadecapeptide BPC 157 is an anti-ulcer peptidergic agent, safe in
inflammatory bowel disease clinical trials (GEPPPGKPADDAGLV, MW 1419, PL 14736) and …

[HTML][HTML] Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and ischemia and reperfusion in rats: New insights

A Duzel, J Vlainic, M Antunovic… - World Journal of …, 2017 - ncbi.nlm.nih.gov
AIM To provide new insights in treatment of colitis and ischemia and reperfusion in rats
using stable gastric pentadecapeptide BPC 157. METHODS Medication [BPC 157, L-NAME …