Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …

For many cancer types, the immune system plays an essential role in their development and
growth. Based on these rather novel insights, immunotherapeutic strategies have been …

The purpose of immunology is simple. Cure or prevent disease. M1/M2 is useful because it
is simple. M1/M2 describes the two major and opposing activities of macrophages. M1 …

M1 and M2 macrophage-type responses kill or repair in vivo. The unique ability of
macrophages to make these polar opposite type of responses provides primary host …

The treatment of metastatic melanoma patients with autologous tumor-infiltrating
lymphocytes (TIL) shows robust, reproducible, clinical responses in clinical trials executed in …

Successful immunotherapy of cancer is becoming a reality aided by the realization that
macrophages play an important role in the growth or regression of tumors. Specifically …

In a recent clinical trial involving patients with metastatic melanoma, immunosuppressive
conditioning with fludarabine and cyclophosphamide resulted in a 50% response rate in …

Publisher Summary This chapter attempts to identify the principles and issues elucidated in
animal models that may provide insights for the development of effective approaches to …

Abstract Purpose: Regulatory T cells (Tregs) have been implicated as inhibitors of
antitumoral immunity, and evidence suggests that elimination of Tregs may augment natural …

The ability of noncytolytic Lyt-1+, 2-T cells immune to FBL-3 leukemia to effect eradication of
disseminated FBL-3 was studied. Adult thymectomized, irradiated, and T-depleted bone …