Sickle cell disease (SCD) is an autosomal recessive disorder characterized by production of
abnormal hemoglobin S and is associated with high morbidity and mortality. Information …

Introduction: Sickle cell disease (SCD) is an inherited blood disorder characterized by
clinical heterogeneity that may be influenced by environmental factors, ethnicity, race, social …

Osteonecrosis of the femoral head (ONFH) is a prevalent complication of sickle cell disease
(SCD) that has not been well described in population-based cohort studies. Using …

Purpose Sickle cell disease (SCD) is a significant burden for patients and healthcare
systems due to multiple factors, including high readmission rates. This study aimed to …

The mechanisms involved in the pathogenesis of osteonecrosis of the femoral head in sickle
cell disease are not fully known. The aim of this study was to identify risk factors for …

Background/objective Sickle cell disease (SCD) is a monogenic disease with multiple
phenotypic expressions. Previous studies describing SCD clinical phenotypes in Nigeria …

Pain, the hallmark complication of sickle cell disease (SCD), is largely managed with opioid
analgesics in the United States, but comprehensive data regarding the long‐term use of …

The haemoglobinopathies are a relatively common, heterogeneous group of inherited
conditions that are the result of either a quantitative abnormality (eg thalassaemia) or …

Osteonecrosis (ON) is a debilitating long-term complication of allogeneic BMT (allo-BMT),
but may begin before allo-BMT in some children because of their primary disease treatment …

Background: Femoral head osteonecrosis (ON) secondary to sickle cell disease (SCD) often
progresses to femoral head collapse, requiring total hip arthroplasty. However, this treatment …