Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology

S Wahab, S Annadurai, SS Abullais, G Das, W Ahmad… - Plants, 2021 - mdpi.com
There are more than 30 species of Glycyrrhiza genus extensively spread worldwide. It was
the most prescribed herb in Ancient Egyptian, Roman, Greek, East China, and the West from …

Chalcone derivatives: role in anticancer therapy

Y Ouyang, J Li, X Chen, X Fu, S Sun, Q Wu - Biomolecules, 2021 - mdpi.com
Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

Heat shock proteins and cancer

J Wu, T Liu, Z Rios, Q Mei, X Lin, S Cao - Trends in pharmacological …, 2017 - cell.com
Heat shock proteins (HSPs) constitute a large family of proteins involved in protein folding
and maturation whose expression is induced by heat shock or other stressors. The major …

Insights into new mechanisms and models of cancer stem cell multidrug resistance

Y Garcia-Mayea, C Mir, F Masson, R Paciucci… - Seminars in cancer …, 2020 - Elsevier
The acquisition of genetic alterations, clonal evolution, and the tumor microenvironment
promote cancer progression, metastasis and therapy resistance. These events correspond …

Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy

CW Yun, HJ Kim, JH Lim, SH Lee - Cells, 2019 - mdpi.com
Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …

Breast cancer stem cells: Features, key drivers and treatment options

J Dittmer - Seminars in cancer biology, 2018 - Elsevier
The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

[HTML][HTML] Natural products as chemo-radiation therapy sensitizers in cancers

S Nisar, T Masoodi, KS Prabhu, S Kuttikrishnan… - Biomedicine & …, 2022 - Elsevier
Cancer is a devastating disease and is the second leading cause of death worldwide.
Surgery, chemotherapy (CT), and/or radiation therapy (RT) are the treatment of choice for …

Role of Medicinal plant‐derived Nutraceuticals as a potential target for the treatment of breast cancer

KS Alharbi, WH Almalki, HA Makeen… - Journal of Food …, 2022 - Wiley Online Library
Breast cancer (BC) is one of the most challenging cancers to treat, accounting for many
cancer‐related deaths. Over some years, chemotherapy, hormone treatment, radiation, and …

Perspectives on the Role of Isoliquiritigenin in Cancer

KL Wang, YC Yu, SM Hsia - Cancers, 2021 - mdpi.com
Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …