Based on evidence that the docked and primed synaptic vesicle state is very dynamic, we
propose a three-step process for the buildup of the molecular machinery that mediates …

As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-
competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles …

Studies on synaptic proteins involved in neurotransmitter release often aim at distinguishing
between their roles in vesicle priming (the docking of synaptic vesicles to the plasma …

During prolonged trains of presynaptic action potentials (APs), synaptic release reaches a
stable level that reflects the speed of replenishment of the readily releasable pool (RRP) …

Chemical synaptic transmission relies on the Ca2+-induced fusion of transmitter-laden
vesicles whose coupling distance to Ca2+ channels determines synaptic release probability …

Central mammalian synapses release synaptic vesicles in dedicated structures called
docking/release sites. It has been assumed that when voltage-dependent calcium entry is …

The concentration of calcium ions in presynaptic terminals regulates transmitter release, but
underlying mechanisms have remained unclear. Here we review recent studies that shed …

Pronounced differences in neurotransmitter release from a given presynaptic neuron,
depending on the synaptic target, are among the most intriguing features of cortical …

Synapses contain a limited number of synaptic vesicles (SVs) that are released in response
to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of …

Synaptic transmission is controlled by re-uptake systems that reduce transmitter
concentrations in the synaptic cleft and recycle the transmitter into presynaptic terminals …