OBJECTIVES: This review was undertaken to describe current understanding of the natural
history of molar pregnancy and persistent gestational trophoblastic neoplasia (GTN) as well …

Gestational trophoblastic neoplasms (GTN) are malignant lesions that arise from placental
villous and extravillous trophoblast. Four clinicopathologic conditions make up this entity:(1) …

This thoroughly revised and updated reference addresses the drugs and chemicals causing
malformations and congenital anomalies in the human fetus-comprehensively reviewing …

Hydatidiform mole, a disorder of fertilization, comprises complete and partial molar
pregnancy. The pathologic and clinical features of complete and partial mole are well …

Gestational trophoblastic neoplasia (GTN) describes a heterogeneous group of interrelated
lesions that arise from abnormal proliferation of placental trophoblasts. GTN lesions are …

The folic acid antagonists, aminopterin and then methotrexate, have been the primary
systemically administered drugs for the treatment of severe psoriasis for 25 years …

The aim of this review is to provide an overview of existing literature and current knowledge
on fertility rates and reproductive outcomes after gestational trophoblastic disease. A …

BACKGROUND: Methotrexate has multiple therapeutic uses in women of reproductive age
including treatment for ectopic pregnancy, neoplastic disease, autoimmune disorders, and …

Objective To assess perinatal outcomes of first pregnancy after remission from gestational
trophoblastic neoplasia and the impact of the time between the end of chemotherapy and …

I n 1948, the original application of antiproliferative cytotoxic chemotherapeutic effects
began with the studies that found the folic acid antagonist aminopterin was an effective …