The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

Bolstered by recent advances in bioinformatics, genetics, and enzyme engineering, the field
of chemoenzymatic synthesis has enjoyed a rapid increase in popularity and utility. This …

Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the
growing number of biocatalysts accessible by means of bioinformatics and enzyme …

Direct C–H bond functionalization catalyzed by non-precious transition metals is an
attractive strategy in synthetic chemistry. Compared with the precious metals rhodium …

Cytochromes P450 (P450 or CYP) are heme-containing enzymes that catalyze the
introduction of one atom of molecular oxygen into nonactivated C–H bonds, often in a regio …

Modified amino acids are important building blocks in both natural biomolecules and
synthetic small-molecule drugs. Here, we review the roles of iron-and α-ketoglutarate …

Structural diversification of lead molecules is a key component of drug discovery to explore
chemical space. Late-stage functionalizations (LSFs) are versatile methodologies capable of …

Steroidal C7β alcohols and their respective esters have shown significant promise as
neuroprotective and anti‐inflammatory agents to treat chronic neuronal damage like stroke …

C14-functionalized steroids display biological activity and have been used as medicines.
The lack of synthetic methods to access C14-functionalized steroids has, however, impeded …