Chemicals used for the induction of Alzheimer's disease-like cognitive dysfunctions in rodents

O Mahdi, MTH Baharuldin, NHM Nor… - Biomedical Research …, 2019 - biomedpress.org
Alzheimer's disease (AD) is the most frequent and multifactorial form of dementia,
characterised by multiple cognitive impairments and personality changes. Different methods …

Regulation of memory function by feeding-relevant biological systems: following the breadcrumbs to the hippocampus

AN Suarez, EE Noble, SE Kanoski - Frontiers in Molecular …, 2019 - frontiersin.org
The hippocampus (HPC) controls fundamental learning and memory processes, including
memory for visuospatial navigation (spatial memory) and flexible memory for facts and …

Gold nanoparticles treatment reverses brain damage in Alzheimer's disease model

N dos Santos Tramontin, S da Silva, R Arruda… - Molecular …, 2020 - Springer
Alzheimer's disease (AD) is characterized by amyloid (A) β peptide accumulation and
intracellular neurofibrillary tangles. New hypotheses have suggested that AD involves …

[HTML][HTML] Design and development of chitosan-insulin-transfersomes (Transfersulin) as effective intranasal nanovesicles for the treatment of Alzheimer's disease: In …

F Nojoki, B Ebrahimi-Hosseinzadeh… - Biomedicine & …, 2022 - Elsevier
This study aimed to prepare and characterize chitosan-Transfersulin (CTI) as an effective
intranasal drug delivery system (IDDS) for the treatment of memory disorders by mediating …

Quercetin stimulates the non-amyloidogenic pathway via activation of ADAM10 and ADAM17 gene expression in aluminum chloride-induced Alzheimer's disease rat …

AM Elfiky, AA Mahmoud, HA Elreedy, KS Ibrahim… - Life sciences, 2021 - Elsevier
Aims Alzheimer's disease (AD) is the most common progressive neurodegenerative disorder
characterized by declined cognitive functions in the elderly. Quercetin (Q) is a potent …

Autophagy-dependent mechanism of genistein-mediated elimination of behavioral and biochemical defects in the rat model of sporadic Alzheimer's disease

K Pierzynowska, M Podlacha, L Gaffke, I Majkutewicz… - …, 2019 - Elsevier
Alzheimer's disease is one of severe neurological diseases for which no effective treatment
is currently available. The use of genistein (5, 7-dihydroxy-3-(4-hydroxyphenyl)-4H-1 …

Brain targeted Polysorbate-80 coated PLGA thymoquinone nanoparticles for the treatment of Alzheimer's disease, with biomechanistic insights

M Yusuf, M Khan, MM Alrobaian, SA Alghamdi… - Journal of Drug Delivery …, 2021 - Elsevier
Thymoquinone (TQ) is a potent phytoconstituent from Nigella sativa and well recognized for
its neuroactivity via antioxidant mechanisms, but its higher lipophilicity and plasma protein …

Gamma subunit of complement component 8 is a neuroinflammation inhibitor

JH Kim, R Afridi, J Han, HG Jung, SC Kim, EM Hwang… - Brain, 2021 - academic.oup.com
The complement system is part of the innate immune system that comprises several small
proteins activated by sequential cleavages. The majority of these complement components …

Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions

MF Zappa Villar, J López Hanotte… - Journal of Neural …, 2018 - Springer
Sporadic Alzheimer's disease (SAD) is the most common form of dementia; therefore, there
is an urgent need for a model that recapitulates the main pathologic hallmarks of this …

Intermittent theta burst stimulation ameliorates cognitive impairment and hippocampal gliosis in the Streptozotocin-induced model of Alzheimer's disease

J Stanojevic, M Dragic, I Stevanovic, T Ilic… - Behavioural Brain …, 2022 - Elsevier
Intracerebroventricularly (icv) injected streptozotocin (STZ) model of Alzheimer's disease
(AD) is used to explore the effect of intermittent theta burst stimulation (iTBS) on astrocyte …