Sepsis remains a significant cause of neonatal mortality and morbidity, especially in low-and
middle-income countries. Neonatal sepsis presents with nonspecific signs and symptoms …

This is a narrative review on the role of biomarkers in the diagnosis of neonatal sepsis. We
describe the difficulties to obtain standardized definitions in neonatal sepsis and discuss the …

Objectives To develop evidence-based recommendations for clinicians caring for children
(including infants, school-aged children, and adolescents) with septic shock and other …

Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …

Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …

Procalcitonin (PCT) and C-reactive protein (CRP) are commonly used biomarkers, but their
diagnostic advantage for neonatal early-onset (EOS) or late-onset (LOS) sepsis is …

Importance Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS),
but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse …

Background Antibiotics are the most common medicines prescribed to children in hospitals
and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse …

Background Neonatal early-onset sepsis (EOS) is one of the main causes of global neonatal
mortality and morbidity, and initiation of early antibiotic treatment is key. However, antibiotics …

Importance The neonatal early-onset sepsis (EOS) calculator is a clinical risk stratification
tool increasingly used to guide the use of empirical antibiotics for newborns. Evidence on …