Surface modification and endothelialization of vascular biomaterials are common
approaches that are used to both resist the nonspecific adhesion of proteins and improve …

Self-assembled synthetic gene delivery systems represent the bottom-up approach to gene
delivery and gene silencing, in which scientists are designing novel cationic and procationic …

Lung cancer is one of the most lethal diseases worldwide, and the survival rate is less than
15% even after the treatment. Unfortunately, chemotherapeutic treatments for lung cancer …

This article discusses the behavior of seven organophosphorus compounds under Atherton–
Todd conditions. Therefore, the reactivity and selectivity of different (phen) oxaphosphinines …

Herein, five new α-tocopheryl cationic gemini lipids with hydroxyethyl bearing headgroups
(THnS, n= 4, 5, 6, 8, 12) have been synthesized for efficient plasmid DNA (pDNA) delivery …

Lipophophoramidates constitute a class of synthetic vectors which were especially designed
for gene delivery. In this family of compounds, the phosphorus functional group links two …

Cationic lipids constitute a family of synthetic vectors commonly used for nucleic acids
delivery. We herein report the results of a systematic study that aimed to compare the …

Lipophosphoramidates have previously been identified as efficient vectors for gene delivery.
The incorporation of functional groups that respond to a physiological stimulus is …

Gene therapy of diseases like cystic fibrosis (CF) would consist of delivering a gene
medicine towards the lungs via the respiratory tract into the target epithelial cells …

The structure of the cationic moiety of amphiphiles is a key factor which directly influences
their transfection efficacy. Accordingly, in the present work, we have synthesized three new …