▪ Abstract Posttranslational modification of proteins by phosphorylation is a universal
mechanism for regulating diverse biological functions. Recognition that many cellular …

Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate
determination, embryonic development, and tissue renewal. As aberrant Hedgehog …

The Wnt/β‐catenin signaling pathway is critical in both cellular proliferation and organismal
development. However, how the β‐catenin degradation complex is inhibited upon Wnt …

A multiple sequence alignment of 44 serine/threonine‐specific protein phosphatases has
been performed. This reveals the position of a common conserved catalytic core, the …

Type 1 protein phosphatases (PP1) are involved in diverse cellular activities, ranging from
glycogen metabolism to chromatin structure modification, mitosis, and meiosis. The …

Abstract Background: Mammalian phosphoinositide 3-kinases (PI 3-kinases) are involved in
receptor-mediated signal transduction and have been implicated in processes such as …

The protein serine/threonine phosphatase 4 (PP4), which localises to centrosomes/spindle
pole bodies in human cells, is shown to exhibit a similar localisation in Drosophila cells and …

We show that the fission yeast dis2 protein phosphatase, which is highly similar to
mammalian type 1 phosphatase, is a phosphoprotein containing phosphoserine (phospho …

Collective cell migration is central to many developmental and pathological processes.
However, the mechanisms that keep cell collectives together and coordinate movement of …

Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory
mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton. We …