Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum
LS Feng, Z Xu, L Chang, C Li, XF Yan… - Medicinal Research …, 2020 - Wiley Online Library
Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …
such as quinolines are crucial to fight against malaria, but malaria control is extremely …
Design of antimalarial agents based on natural products
J Jampilek - Current Organic Chemistry, 2017 - ingentaconnect.com
Background: Despite the successes achieved recently in the treatment of various infectious
diseases, the morbidity and mortality associated with malaria remain major burdens …
diseases, the morbidity and mortality associated with malaria remain major burdens …
Plasmodium falciparum Werner homologue is a nuclear protein and its biochemical activities reside in the N-terminal region
RecQ helicases, also addressed as a gatekeeper of genome, are an inevitable family of
genome scrutiny proteins conserved from prokaryotes to eukaryotes and play a vital role in …
genome scrutiny proteins conserved from prokaryotes to eukaryotes and play a vital role in …
A Green Synthesis of Fused Polycyclic 5H-Chromeno[3,2-c]quinoline-6,8(7H,9H)-dione Derivatives Catalyzed by TsOH in Ionic Liquids
JC Shen, RZ Jin, K Yuan, MM Zhang… - Polycyclic Aromatic …, 2016 - Taylor & Francis
A three-component reaction of benzaldehyde, 5, 5-dimethyl-3-(arylamino) cyclohex-2-enone
and 4-hydroxyquinolin-2 (1 H)-one gave a series of 3-((4, 4-dimethyl-6-oxo-2-(arylamino) …
and 4-hydroxyquinolin-2 (1 H)-one gave a series of 3-((4, 4-dimethyl-6-oxo-2-(arylamino) …
3-Iodo-4-aminoquinoline derivative sensitises resistant strains of Plasmodium falciparum to chloroquine
S Edaye, D Tazoo, DS Bohle, E Georges - International journal of …, 2016 - Elsevier
Chloroquine (CQ), the first cost-effective synthetic antimalarial, is rendered ineffective in
malaria-endemic regions owing to the rise and spread of CQ-resistant Plasmodium …
malaria-endemic regions owing to the rise and spread of CQ-resistant Plasmodium …
A synthetic approach to PW2‐Like compounds
PS Forastieri, LE Luna, RM Cravero… - …, 2020 - Wiley Online Library
The 9H‐xanthene derivatives, like PW2, displayed a wide spectrum of bioactivities. Herein,
we reported a rapid and simple synthetic route for compounds containing the xanthenic …
we reported a rapid and simple synthetic route for compounds containing the xanthenic …