Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity
and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and …

Endothelial cells line the lumen of all blood vessels and play a critical role in maintaining the
barrier function of the vasculature. Sealing of the vessel wall between adjacent endothelial …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence.
Diseased tissues are heavily vascularized. Surprisingly, the pathogenic impact of the …

Chronic inflammatory rheumatic diseases (IRD), including rheumatoid arthritis, ankylosing
spondylitis, and psoriatic arthritis, are prevalent conditions worldwide, with a considerable …

Inflammatory bowel diseases (IBDs) consist of a group of chronic inflammatory disorders
with a complex etiology, which represent a clinical challenge due to their often therapy …

The decrease of endothelial barrier function is central to the long-term inflammatory
response. A pathological alteration of the ability of endothelial cells to modulate the passage …

Aims Microvascular endothelial barrier breakdown in sepsis precedes organ failure and
death in patients. We tested the hypothesis that the formation of endothelium-derived …

Recruitment of circulating monocytes is critical for tumour angiogenesis. However, how
human monocyte subpopulations extravasate to tumours is unclear. Here we show …

Angiogenesis is de novo capillary outgrowth from pre-existing blood vessels. This process
not only is crucial for normal development, but also has an important role in supplying …

Background Vascular endothelial cadherin (VE-cadherin) is a membrane protein that is the
major component of adherens junctions between endothelial cells. It is crucial for regulating …