[HTML][HTML] The biological pathways of Alzheimer disease: A review

M Calabrò, C Rinaldi, G Santoro, C Crisafulli - AIMS neuroscience, 2021 - ncbi.nlm.nih.gov
Alzheimer disease is a progressive neurodegenerative disorder, mainly affecting older
people, which severely impairs patients' quality of life. In the recent years, the number of …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

A review on advances of treatment modalities for Alzheimer's disease

ES Thoe, A Fauzi, YQ Tang, S Chamyuang, AYY Chia - Life sciences, 2021 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Acetylcholinesterase inhibitors: pharmacology and toxicology

MB Colovic, DZ Krstic… - Current …, 2013 - ingentaconnect.com
Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …

The state of the art on acetylcholinesterase inhibitors in the treatment of Alzheimer's disease

I Vecchio, L Sorrentino, A Paoletti… - Journal of Central …, 2021 - journals.sagepub.com
Alzheimer's disease (AD) is a chronic disabling disease that affects the central nervous
system. The main consequences of AD include the decline of cognitive functions and …

Mild cognitive impairment and mild dementia: a clinical perspective

DS Knopman, RC Petersen - Mayo Clinic Proceedings, 2014 - Elsevier
Mild cognitive impairment and mild dementia are common problems in the elderly. Primary
care physicians are the first point of contact for most patients with these disorders and …

New insights into drug discovery targeting tau protein

Y Soeda, A Takashima - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Microtubule-associated protein tau is characterized by the fact that it is an intrinsically
disordered protein due to its lack of a stable conformation and high flexibility. Intracellular …

Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine

F Zemek, L Drtinova, E Nepovimova… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a world-wide health problem with implications for
an increasing number of people and countries. Populations suffering from AD financially …

Meta-analysis of randomized controlled trials on the efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's …

DD Li, YH Zhang, W Zhang, P Zhao - Frontiers in neuroscience, 2019 - frontiersin.org
To study the impact of donepezil, rivastigmine, galantamine, and memantine on cognitive,
functional, behavioral, global changes and adverse effects in patients with mild, moderate …

Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer's disease: a network meta-analysis of 41 randomized controlled trials

KX Dou, MS Tan, CC Tan, XP Cao, XH Hou… - Alzheimer's research & …, 2018 - Springer
Background Cholinesterase inhibitors and memantine have been approved for
management of Alzheimer's disease (AD), but there has been no consensus about the …