The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …

Tumors are populated by antigen-presenting cells (APCs) including macrophage subsets
with distinct origins and functions. Here, we examined how cancer impacts mononuclear …

Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that
receptor activation unequivocally indicates the presence of something foreign. However, a …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Macrophages are critical mediators of tissue homeostasis, with tumours distorting this
proclivity to stimulate proliferation, angiogenesis and metastasis. This had led to an interest …

Resident tissue macrophages (RTMs) have a broad spectrum of immune-and non-immune-
related tissue-supporting activities. The roots of this heterogeneity and versatility are only …

Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …