Complexes of ruthenium (II) as promising dual-active agents against cancer and viral infections

A D'Amato, A Mariconda, D Iacopetta, J Ceramella… - Pharmaceuticals, 2023 - mdpi.com
Poor responses to medical care and the failure of pharmacological treatment for many high-
frequency diseases, such as cancer and viral infections, have been widely documented. In …

From Concept to Cure: The Road Ahead for Ruthenium‐Based Anticancer Drugs

S Swaminathan, J Haribabu, R Karvembu - ChemMedChem, 2024 - Wiley Online Library
The evolution of chemotherapy, especially the dawn of metal‐based drugs, represents a
transformative era in cancer treatment. From the serendipitous discovery of mustard gas's …

Aminocarbyne-Alkyne Coupling in Diruthenium Complexes: Exploring the Anticancer Potential of the Resulting Vinyliminium Complexes and Comparison with Diiron …

B Bertoncini, Z Xiao, S Zacchini, L Biancalana… - Inorganic …, 2024 - ACS Publications
New diruthenium complexes based on the scaffold Ru2Cp2 (CO) 2 (Cp= η5-C5H5) and
containing a bridging vinyliminium ligand,[2a–d] CF3SO3, were synthesized through …

Ligand Characterization and DNA Intercalation of Ru (II) Polypyridyl Complexes: A Local Vibrational Mode Study

H La Force, M Freindorf, E Kraka - The Journal of Physical …, 2024 - ACS Publications
We investigated in this work ruthenium-ligand bonding across the RuN framework in 12 Ru
(II) polypyridyl complexes in the gas phase and solution for both singlet and triplet states, in …

Polydiacetylene/lipid-coated red-emissive silica nanorods for the sustained release and ameliorated anticancer efficacy of a Ru (arene) complex bearing …

W Ishaniya, C Sumithaa, M Subramani… - Dalton …, 2024 - pubs.rsc.org
A suitable drug delivery strategy for metallodrugs is as significant as the strategies adopted
for an efficient metallodrug design. In this study, piperlongumine, which is isolated from long …

Ruthenium complexes with abiraterone acetate as antiproliferative agents

AA Antonets, EV Spitsyna, VY Tyurin, DM Mazur… - Journal of Inorganic …, 2025 - Elsevier
This study is dedicated to the development of multimodal anticancer agents. We have
obtained ruthenium complexes conjugated with the steroid-type antitumor drug abiraterone …

Copper (I) complexes of acylthiourea ligands: structural insights and cytotoxic potential

PA Doss, M Dharmasivam… - Applied …, 2024 - Wiley Online Library
The reaction of substituted acylthiourea derivatives (L1–L4) with [(PPh3) 2Cu (μ‐Cl) 2Cu
(PPh3)] in a proper stoichiometric proportion gave the complexes (1–4) in good yields. The …

Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion

S Nandhini, M Ranjani, G Thiruppathi… - Journal of Inorganic …, 2024 - Elsevier
Abstract Four Ru (II) complexes (A2-A5) were synthesized from the reaction of coumarin
Schiff base ligands (7da2-tsc, 7da3-mtsc, 7da4-etsc and 7da5-ptsc) with [RuHCl (CO)(PPh …

[HTML][HTML] Catalytic reactions promoted by metal complexes stabilized by 1, 3, 5-triaza-7-phosphatricyclo [3.3. 1.1] decane (PTA) and derivatives. A brief survey of recent …

A Guerriero, L Gonsalvi - Inorganica Chimica Acta, 2024 - Elsevier
In this review article, we present a brief survey of the recent contributions (2018–2024)
appeared in the scientific literature, describing the use of the cage-like water-soluble …

Synthesis, Structural Elucidation, Density Functional Theory Calculations, In Vitro Antimicrobial, Anti‐Inflammatory and Anticancer Activities of Novel Zn (II)‐Group …

Mamta, A Chaudhary - Applied Organometallic Chemistry, 2024 - Wiley Online Library
In the present work, new heterobimetallic complexes with the general formula [Zn
(C16H32N8) M2 (R) 4Cl2], where M= Sn (IV) and Si (IV) and R=‐CH3 and‐C6H5, were …