Bacteriophage λ, rediscovered in the early 1950s, has served as a model in molecular
biology studies for decades. Although currently more complex organisms and more …

The morbidity and mortality caused by the globally prevalent human respiratory pathogen
respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously …

Although characterization of the genotype has undergone revolutionary advances as a
result of the successful genome projects, the chasm between our understanding of a fully …

DNA looping mediated by transcription factors plays critical roles in prokaryotic gene
regulation. The “genetic switch” of bacteriophage λ determines whether a prophage stays …

The bistable gene regulatory switch controlling the transition from lysogeny to lysis in
bacteriophage λ presents a unique challenge to quantitative modeling. Despite extensive …

Abstract Systems biology aims at integrating processes at various time and spatial scales
into a single and coherent formal description to allow computer modeling. In this context, we …

The genetic switch of phage lambda provides a paradigm for studying developmental
biology and cell fate. Although there have been numerous experimental and theoretical …

According to the chemical kinetic model of lysogeny/lysis switch in Escherichia coli (E. coli)
infected by bacteriophage λ, the entropy production rates of steady states are calculated …

The lysogenic state of bacteriophage lambda has been a key model for understanding gene
regulation. A single protein, CI repressor, maintains this state by blocking gene expression …

The morbidity and mortality caused by the globally prevalent human respiratory pathogen
respiratory syncytial virus (RSV) approaches that world-wide of influenza. We previously …