HIV-1 assembly, release and maturation

EO Freed - Nature reviews microbiology, 2015 - nature.com
Major advances have occurred in recent years in our understanding of HIV-1 assembly,
release and maturation, as work in this field has been propelled forwards by developments …

Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance

G Enkavi, M Javanainen, W Kulig, T Róg… - Chemical …, 2019 - ACS Publications
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …

HIV-1 assembly, budding, and maturation

WI Sundquist, HG Kräusslich - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
A defining property of retroviruses is their ability to assemble into particles that can leave
producer cells and spread infection to susceptible cells and hosts. Virion morphogenesis …

The structural biology of HIV-1: mechanistic and therapeutic insights

A Engelman, P Cherepanov - Nature Reviews Microbiology, 2012 - nature.com
Three-dimensional molecular structures can provide detailed information on biological
mechanisms and, for cases in which the molecular function affects human health, can …

Revitalizing membrane rafts: new tools and insights

K Simons, MJ Gerl - Nature reviews Molecular cell biology, 2010 - nature.com
Ten years ago, we wrote a Review on lipid rafts and signalling in the launch issue of Nature
Reviews Molecular Cell Biology. At the time, this field was suffering from ambiguous …

Fc‐fusion proteins: new developments and future perspectives

DM Czajkowsky, J Hu, Z Shao… - EMBO molecular medicine, 2012 - embopress.org
Since the first description in 1989 of CD4‐Fc‐fusion antagonists that inhibit human immune
deficiency virus entry into T cells, Fc‐fusion proteins have been intensely investigated for …

HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation

MA Checkley, BG Luttge, EO Freed - Journal of molecular biology, 2011 - Elsevier
The HIV-1 envelope (Env) glycoproteins play an essential role in the virus replication cycle
by mediating the fusion between viral and cellular membranes during the entry process. The …

Fatty acylation of proteins: The long and the short of it

MD Resh - Progress in lipid research, 2016 - Elsevier
Long, short and medium chain fatty acids are covalently attached to hundreds of proteins.
Each fatty acid confers distinct biochemical properties, enabling fatty acylation to regulate …

Multifaceted roles for lipids in viral infection

NS Heaton, G Randall - Trends in microbiology, 2011 - cell.com
Viruses have evolved complex and dynamic interactions with their host cell. In recent years
we have gained insight into the expanding roles for host lipids in the virus life cycle. In …

Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis

SB Kutluay, T Zang, D Blanco-Melo, C Powell… - Cell, 2014 - cell.com
The HIV-1 Gag protein orchestrates all steps of virion genesis, including membrane
targeting and RNA recruitment into virions. Using crosslinking-immunoprecipitation (CLIP) …