Mechanical regulation of bone remodeling
Bone remodeling is a lifelong process that gives rise to a mature, dynamic bone structure via
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …
a balance between bone formation by osteoblasts and resorption by osteoclasts. These …
A second space age spanning omics, platforms and medicine across orbits
The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Spaceflight induces an immune response in astronauts. To better characterize this effect, we
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
generated single-cell, multi-ome, cell-free RNA (cfRNA), biochemical, and hematology data …
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Spaceflight induces molecular, cellular and physiological shifts in astronauts and poses
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
myriad biomedical challenges to the human body, which are becoming increasingly relevant …
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …
Biomonitoring and precision health in deep space supported by artificial intelligence
Human exploration of deep space will involve missions of substantial distance and duration.
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …
To effectively mitigate health hazards, paradigm shifts in astronaut health systems are …
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …
of spaceflight on the human body. Biospecimen samples were collected from four crew …
Current knowledge about the impact of microgravity on gene regulation
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …
Next generation of astronauts or ESA astronaut 2.0 concept and spotlight on immunity
P Jacob, C Oertlin, B Baselet, LS Westerberg… - npj …, 2023 - nature.com
Although we have sent humans into space for more than 50 years, crucial questions
regarding immune response in space conditions remain unanswered. There are many …
regarding immune response in space conditions remain unanswered. There are many …