Background: Until recently, few treatments were available for renal cell carcinoma (RCC)
and gastrointestinal stromal tumors (GIST). Several targeted agents inhibiting key …

Primary chest wall tumors are a heterogenous group of neoplasms arising from bone, soft
tissue, or cartilage of the chest wall. They are rare tumors, with an incidence of 2% of the …

Purpose Given the importance of angiogenesis in soft tissue sarcoma (STS), pazopanib, an
oral angiogenesis inhibitor that targets vascular endothelial growth factor receptor and …

PURPOSE: New agents are needed for patients with metastatic uterine leiomyosarcoma
who progress after treatment with doxorubicin or gemcitabine-docetaxel. Agents targeting …

Background To assess the response of patients with soft tissue sarcoma (STS) to the
combination of docetaxel, bevacizumab, and gemcitabine. Vascular endothelial growth …

Uterine leiomyosarcomas (LMSs) are rare tumors, comprising 1.3% of all uterine cancers.
Primary therapy for localized disease entails complete surgical resection. The majority of …

Soft tissue sarcomas (STSs) are a heterogeneous group of malignancies that includes> 50
different subtypes, each with unique clinical and pathologic qualities. In general, there is a …

Soft tissue sarcomas (STS) are rare diseases, with an estimated 10,390 new cases in the
United States in 2008. Unfortunately, only 50% are cured with surgical resection. The …

Pazopanib, a tyrosine kinase inhibitor targeted to angiogenesis, has been tested in
preclinical and clinical trials and has shown promising activity against a variety of solid …

Поскольку саркомы мягких тканей (СМТ) относятся к опухолям с высокой вас
куляризацией [1 5], ангиогенез играет ключевую роль в их развитии и метастази …