Simple Summary Neuroblastoma is one of the most diffuse and the deadliest cancer in
children. While many advances have been made in the last few decades to improve patients' …

Personalized medicine represents a major goal in oncology. It has its underpinning in the
identification of biomarkers with diagnostic, prognostic, or predictive values. Nowadays, the …

Background Development of resistance to targeted therapies has tempered initial optimism
that precision oncology would improve poor outcomes for cancer patients. Resistance …

Background: Sarcopenia describes a generalized loss of skeletal muscle mass, strength, or
function. Determined by measuring the total psoas muscle area (tPMA) on cross-sectional …

PRIMAGE is one of the largest and more ambitious research projects dealing with medical
imaging, artificial intelligence and cancer treatment in children. It is a 4-year European …

Background: The optimal choice of initial antibiotic therapy for patients with high-risk febrile
neutropenia (FN) in children is unclear and varies by the institution on the basis of local …

Background Neuroblastoma (NB) is the most frequent extracranial solid tumor in children.
More than 50% of patients present with widespread (stage M) or refractory disease. In these …

Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have
been identified for single circRNAs, how they modulate gene expression in cancer is not …

Background Certain paediatric nervous system malignancies have dismal prognoses.
Retinoic acid (RA) is used in neuroblastoma treatment, and preclinical data indicate …

PURPOSE Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the
contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical …