Architecture of the mitochondrial calcium uniporter
Mitochondria from many eukaryotic clades take up large amounts of calcium (Ca2+) via an
inner membrane transporter called the uniporter. Transport by the uniporter is membrane …
inner membrane transporter called the uniporter. Transport by the uniporter is membrane …
4.0-Å resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement
Y Cong, ML Baker, J Jakana… - Proceedings of the …, 2010 - National Acad Sciences
The essential double-ring eukaryotic chaperonin TRiC/CCT (TCP1-ring complex or
chaperonin containing TCP1) assists the folding of∼ 5–10% of the cellular proteome. Many …
chaperonin containing TCP1) assists the folding of∼ 5–10% of the cellular proteome. Many …
PRIME: probabilistic initial 3D model generation for single-particle cryo-electron microscopy
Low-dose electron microscopy of cryo-preserved individual biomolecules (single-particle
cryo-EM) is a powerful tool for obtaining information about the structure and dynamics of …
cryo-EM) is a powerful tool for obtaining information about the structure and dynamics of …
Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography
The past few decades have seen tremendous advances in single-particle electron cryo-
microscopy (cryo-EM). The field has matured to the point that near-atomic resolution density …
microscopy (cryo-EM). The field has matured to the point that near-atomic resolution density …
Single particle analysis at high resolution
Y Cong, SJ Ludtke - Methods in enzymology, 2010 - Elsevier
Electron cryomicroscopy (cryo-EM) and single particle analysis is emerging as a powerful
technique for determining the 3D structure of large biomolecules and biomolecular …
technique for determining the 3D structure of large biomolecules and biomolecular …
Symmetry‐free cryo‐EM structures of the chaperonin TRiC along its ATPase‐driven conformational cycle
The eukaryotic group II chaperonin TRiC/CCT is a 16‐subunit complex with eight distinct but
similar subunits arranged in two stacked rings. Substrate folding inside the central chamber …
similar subunits arranged in two stacked rings. Substrate folding inside the central chamber …
Rapid solution of the cryo-EM reconstruction problem by frequency marching
A Barnett, L Greengard, A Pataki, M Spivak - SIAM Journal on Imaging …, 2017 - SIAM
Determining the three-dimensional (3D) structure of proteins and protein complexes at
atomic resolution is a fundamental task in structural biology. Over the last decade …
atomic resolution is a fundamental task in structural biology. Over the last decade …
Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy
Y Cong, Q Zhang, D Woolford, T Schweikardt, H Khant… - Structure, 2009 - cell.com
Phenoloxidases (POs) occur in all organisms and are involved in skin and hair coloring in
mammals, and initiating melanization in wound healing. Mutation or overexpression of PO …
mammals, and initiating melanization in wound healing. Mutation or overexpression of PO …
Pre-pro is a fast pre-processor for single-particle cryo-EM by enhancing 2D classification
Abstract 2D classification plays a pivotal role in analyzing single particle cryo-electron
microscopy images. Here, we introduce a simple and loss-less pre-processor that …
microscopy images. Here, we introduce a simple and loss-less pre-processor that …
Cryo-EM image alignment based on nonuniform fast Fourier transform
Z Yang, PA Penczek - Ultramicroscopy, 2008 - Elsevier
In single particle analysis, two-dimensional (2-D) alignment is a fundamental step intended
to put into register various particle projections of biological macromolecules collected at the …
to put into register various particle projections of biological macromolecules collected at the …