Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Abundant filamentous inclusions of tau are characteristic of more than 20
neurodegenerative diseases that are collectively termed tauopathies. Electron cryo …

The tauopathies constitute a group of diseases that have Tau inclusions in neurons or glia
as their common denominator. In this review, we describe the biochemical and histological …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Tau phosphorylation is regulated by a balance between tau kinase and phosphatase
activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau …

Less than 50 years since tau was first isolated from a porcine brain, its detection in femtolitre
concentrations in biological fluids is revolutionizing the diagnosis of neurodegenerative …

Aggregates of the microtubule-associated protein tau are a defining feature of several
neurodegenerative diseases that are collectively known as tauopathies, and constitute one …

Alzheimer′ s disease (AD) is the most common type of dementia. In connection with the
global trend of prolonging human life and the increasing number of elderly in the population …

Alzheimer's disease (AD) belongs to a group of neurodegenerative diseases collectively
designated as “tauopathies”, because they are characterized by the aggregation of …