Tryptophan metabolism, from nutrition to potential therapeutic applications

N Le Floc'h, W Otten, E Merlot - Amino acids, 2011 - Springer
Tryptophan is an indispensable amino acid that should to be supplied by dietary protein.
Apart from its incorporation into body proteins, tryptophan is the precursor for serotonin, an …

L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications

DM Richard, MA Dawes, CW Mathias… - International …, 2009 - journals.sagepub.com
An essential component of the human diet, L-tryptophan is critical in a number of metabolic
functions and has been widely used in numerous research and clinical trials. This review …

Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: what depression has in common with impulsive aggression.

CS Carver, SL Johnson, J Joormann - Psychological bulletin, 2008 - psycnet.apa.org
Evidence from diverse literatures supports the viewpoint that two modes of self-regulation
exist, a lower-order system that responds quickly to associative cues of the moment and a …

The serotonergic system in ageing and Alzheimer's disease

JJ Rodríguez, HN Noristani, A Verkhratsky - Progress in neurobiology, 2012 - Elsevier
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates
cognitive functions and primarily affects associated brain regions involved in learning and …

Sex differences in learning processes of classical and operant conditioning

C Dalla, TJ Shors - Physiology & behavior, 2009 - Elsevier
Males and females learn and remember differently at different times in their lives. These
differences occur in most species, from invertebrates to humans. We review here sex …

Effects of tryptophan loading on human cognition, mood, and sleep

BY Silber, JAJ Schmitt - Neuroscience & biobehavioral reviews, 2010 - Elsevier
Modulating central serotonergic function by acute tryptophan depletion (ATD) has provided
the fundamental insights into which cognitive functions are influenced by serotonin. It may …

The role of 5-HT1A receptors in learning and memory

SO Ögren, TM Eriksson, E Elvander-Tottie… - Behavioural brain …, 2008 - Elsevier
The ascending serotonin (5-HT) neurons innervate the cerebral cortex, hippocampus,
septum and amygdala, all representing brain regions associated with various domains of …

Revisiting the serotonin–aggression relation in humans: A meta-analysis.

AA Duke, L Bègue, R Bell… - Psychological bulletin, 2013 - psycnet.apa.org
The inverse relation between serotonin and human aggression is often portrayed as
“reliable,”“strong,” and “well established” despite decades of conflicting reports and widely …

Cognitive effects of methylphenidate in healthy volunteers: a review of single dose studies

AMW Linssen, A Sambeth… - International journal …, 2014 - academic.oup.com
Methylphenidate (MPH), a stimulant drug with dopamine and noradrenaline reuptake
inhibition properties, is mainly prescribed in attention deficit hyperactivity disorder, is …

Sex differences in tryptophan metabolism: A systematic review focused on neuropsychiatric disorders

ML Pais, J Martins, M Castelo-Branco… - International Journal of …, 2023 - mdpi.com
Tryptophan (Tryp) is an essential amino acid and the precursor of several neuroactive
compounds within the central nervous system (CNS). Tryp metabolism, the common …