Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Proper control of Ca2+ signaling is mandatory for effective cell migration, which is critical for
embryonic development, wound healing, and cancer metastasis. However, how Ca2+ …

Ca2+ signaling has been increasingly implicated in cancer invasion and metastasis, and
yet, the underlying mechanisms remained largely unknown. In this paper, we report that …

In squamous cell carcinoma (SCC), tissue invasion by collectively invading cells requires
physical forces applied by tumor cells on their surrounding extracellular matrix (ECM) …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

Mammalian oocyte maturation is a unique asymmetric division, which is mainly because of
actin-based spindle migration to the cortex. In the present study, we report that a kinesin …

Store-operated calcium entry (SOCE) is the predominant calcium entry mechanism in most
cancer cells. SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 …

Simple Summary Histone deacetylase inhibitors (HDACIs) are a relatively new drug class
with important effects on the epigenetic regulation in cancer, inducing cancer cell death …

The ion Ca 2+ is a ubiquitous second messenger that mediates a variety of cellular
functions. Dysfunction of the mechanisms involved in Ca 2+ homeostasis underlies a …