Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis
V Brinkmann, A Billich, T Baumruker… - Nature reviews Drug …, 2010 - nature.com
The discovery of fingolimod (FTY720/Gilenya; Novartis), an orally active immunomodulatory
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
drug, has opened up new approaches to the treatment of multiple sclerosis, the most …
Lysophospholipid receptors: signaling and biology
▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental …
Crystal structure of a lipid G protein–coupled receptor
The lyso-phospholipid sphingosine 1-phosphate modulates lymphocyte trafficking,
endothelial development and integrity, heart rate, and vascular tone and maturation by …
endothelial development and integrity, heart rate, and vascular tone and maturation by …
Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84
GPR84 is an orphan class AG protein-coupled receptor (GPCR) that is predominantly
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
expressed in immune cells and plays important roles in inflammation, fibrosis, and …
Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate
Sphingosine 1-phosphate (S1P) influences heart rate, coronary artery caliber, endothelial
integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled …
integrity, and lymphocyte recirculation through five related high affinity G-protein-coupled …
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate
EL Laviad, L Albee, I Pankova-Kholmyansky… - Journal of Biological …, 2008 - ASBMB
Ceramide is an important lipid signaling molecule and a key intermediate in sphingolipid
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide …
biosynthesis. Recent studies have implied a previously unappreciated role for the ceramide …
CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4
AJ Bankovich, LR Shiow, JG Cyster - Journal of Biological Chemistry, 2010 - ASBMB
Lymphocyte egress from lymph nodes requires the G-protein-coupled sphingosine 1-
phosphate receptor-1 (S1P 1). The activation antigen CD69 associates with and inhibits the …
phosphate receptor-1 (S1P 1). The activation antigen CD69 associates with and inhibits the …
Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
H Rosen, EJ Goetzl - Nature Reviews Immunology, 2005 - nature.com
Abstract Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that
transmits signals through a family of G-protein-coupled receptors to control cellular …
transmits signals through a family of G-protein-coupled receptors to control cellular …
Altered lipid metabolism in brain injury and disorders
RM Adibhatla, JF Hatcher - Lipids in health and disease, 2008 - Springer
Deregulated lipid metabolism may be of particular importance for CNS injuries and
disorders, as this organ has the highest lipid concentration next to adipose tissue …
disorders, as this organ has the highest lipid concentration next to adipose tissue …
[PDF][PDF] Conjugated bile acids activate the sphingosine‐1‐phosphate receptor 2 in primary rodent hepatocytes
Bile acids have been shown to be important regulatory molecules for cells in the liver and
gastrointestinal tract. They can activate various cell signaling pathways including …
gastrointestinal tract. They can activate various cell signaling pathways including …