Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static
entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …

The correct establishment and maintenance of cell polarity are crucial for normal cell
physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …

Regulated protein-protein interactions are critical for cell signaling, differentiation, and
development. For the study of dynamic regulation of protein interactions in vivo, there is a …

PAR proteins constitute a highly conserved network of scaffolding proteins, adaptors and
enzymes that form and stabilize cortical asymmetries in response to diverse inputs. They …

Cell rearrangements shape the Drosophila embryo via spatially regulated changes in cell
shape and adhesion. We show that Bazooka/Par-3 (Baz) is required for the planar polarized …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …