The~ 100 MB genome of C. elegans codes for~ 20,000 protein-coding genes many of which
are required for the function of the nervous system, composed of 302 neurons in the adult …

The use of next-generation sequencing (NGS) has revolutionized the way phenotypic traits
are assigned to genes. In this review, we describe NGS-based methods for mapping a …

Whole genome sequencing (WGS) allows researchers to pinpoint genetic differences
between individuals and significantly shortcuts the costly and time-consuming part of …

Whole-genome sequencing (WGS) is becoming a fast and cost-effective method to pinpoint
molecular lesions in mutagenized genetic model systems, such as Caenorhabditis elegans …

Appetitive behaviors require complex decision making that involves the integration of
environmental stimuli and physiological needs. C. elegans mate searching is a male …

The plant corepressor TOPLESS (TPL) is recruited to a large number of loci that are
selectively induced in response to developmental or environmental cues, yet the …

Whole-genome sequencing (WGS) of organisms displaying a specific mutant phenotype is a
powerful approach to identify the genetic determinants of a plethora of biological processes …

The Groucho transcriptional corepressor TLE1 protein has recently been shown to be a
putative lung specific oncogene, but its underlying oncogenic activity in lung cancer has not …

Corepressors are proteins that cannot bind DNA directly but repress transcription by
interacting with partner proteins. The Groucho/Transducin‐Like Enhancer of Split (TLE) are …

Abstract Drosophila Groucho (Gro) is the founding member of a family of metazoan
corepressors. Gro mediates repression through interactions with a myriad of DNA-binding …