Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat …

Brain function relies on the ability of neural networks to maintain stable levels of activity,
while experiences sculpt them. In the neocortex, the balance between activity and stability …

Loss-of-function mutations in the gene encoding the postsynaptic scaffolding protein
SHANK2 are a highly penetrant cause of autism spectrum disorders (ASD) involving …

Background Human genetic and genomic studies have supported a strong causal role of
SHANK3 deficiency in autism spectrum disorder (ASD). However, the molecular mechanism …

ASD research is at an important crossroads. The ASD diagnosis is important for assigning a
child to early behavioral intervention and explaining a child's condition. But ASD research …

Autism spectrum disorder (ASD) is comprised of several conditions characterized by
alterations in social interaction, communication, and repetitive behaviors. Genetic and …

The corticostriatal pathway that carries sensory, motor, and limbic information to the striatum
plays a critical role in motor control, action selection, and reward. Dysfunction of this …

Vitamin D deficiency/insufficiency is a public health issue around the world. According to
epidemiological studies, low vitamin D levels have been associated with an increased risk of …

Shank3 is a synaptic scaffolding protein that assists in tethering and organizing structural
proteins and glutamatergic receptors in the postsynaptic density of excitatory synapses. The …

The postsynaptic density (PSD), apparent in electron micrographs as a dense lamina just
beneath the postsynaptic membrane, includes a deeper layer, the “pallium”, containing a …