Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

DF Niño, CP Sodhi, DJ Hackam - Nature reviews Gastroenterology & …, 2016 - nature.com
Necrotizing enterocolitis (NEC) is the most frequent and lethal disease of the gastrointestinal
tract of preterm infants. At present, NEC is thought to develop in the premature host in the …

Necrotizing enterocolitis

J Duchon, ME Barbian… - Clinics in …, 2021 - perinatology.theclinics.com
Necrotizing enterocolitis (NEC) is a devastating intestinal disorder characterized by
intestinal inflammation and necrosis. 1 This disease is one of the most common …

Dynamics of the preterm gut microbiome in health and disease

A Cuna, MJ Morowitz, I Ahmed… - American Journal of …, 2021 - journals.physiology.org
Advances in metagenomics have allowed a detailed study of the gut microbiome, and its
role in human health and disease. Infants born prematurely possess a fragile gut microbial …

Prospecting human milk oligosaccharides as a defense against viral infections

RE Moore, LL Xu, SD Townsend - ACS infectious diseases, 2021 - ACS Publications
In addition to providing maximal nutritional value for neonatal growth and development,
human milk functions as an early defense mechanism against invading pathogens. Human …

Gut and lung microbiota in preterm infants: immunological modulation and implication in neonatal outcomes

C Tirone, L Pezza, A Paladini, M Tana… - Frontiers in …, 2019 - frontiersin.org
In recent years, an aberrant gastrointestinal colonization has been found to be associated
with an higher risk for postnatal sepsis, necrotizing enterocolitis (NEC) and growth …

Unraveling the microbiome of necrotizing enterocolitis: insights in novel microbial and metabolomic biomarkers

C Tarracchini, C Milani, G Longhi, F Fontana… - Microbiology …, 2021 - Am Soc Microbiol
Necrotizing enterocolitis (NEC) is among the most relevant gastrointestinal diseases
affecting mostly prematurely born infants with low birth weight. While intestinal dysbiosis has …

[HTML][HTML] Early-life formula feeding is associated with infant gut microbiota alterations and an increased antibiotic resistance load

KMM Pärnänen, J Hultman, M Markkanen… - The American journal of …, 2022 - Elsevier
Background Infants are at a high risk of acquiring fatal infections, and their treatment relies
on functioning antibiotics. Antibiotic resistance genes (ARGs) are present in high numbers in …

Pathogenesis of NEC: impact of an altered intestinal microbiome

J Neu, M Pammi - Seminars in perinatology, 2017 - Elsevier
Necrotizing enterocolitis (NEC), a disease most commonly seen in preterm infants, often
presents without warning and is associated with very high mortality and morbidity. Progress …

Metagenomic insights of the infant microbiome community structure and function across multiple sites in the United States

G Casaburi, RM Duar, H Brown, RD Mitchell, S Kazi… - Scientific reports, 2021 - nature.com
The gut microbiome plays an important role in early life, protecting newborns from enteric
pathogens, promoting immune system development and providing key functions to the infant …

Exploring the role of the microbiota member Bifidobacterium in modulating immune-linked diseases

I O'Neill, Z Schofield, LJ Hall - Emerging topics in life sciences, 2017 - portlandpress.com
The gut-associated microbiota is essential for multiple physiological processes, including
immune development. Acquisition of our initial pioneer microbial communities, including the …