Cancer is the second leading cause of death worldwide and disease burden is expected to
increase globally throughout the next several decades, with the majority of cancer-related …

Genetic material is organized in the form of chromosomes, which need to be segregated
accurately into two daughter cells in each cell cycle. However, chromosome fusion or the …

Chromosomal instability (CIN) generates micronuclei—aberrant extranuclear structures that
catalyze the acquisition of complex chromosomal rearrangements present in cancer …

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with
aneuploidy-induced cellular stresses remain largely unknown. Here, we induce …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet
the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle …

Aneuploidy—the karyotype state in which the number of chromosomes deviates from a
multiple of the haploid chromosome set—is common in cancer, where it is thought to …

Chromosomal instability (CIN), an increased rate of changes in chromosome structure and
number, is observed in most sporadic human carcinomas with high metastatic activity. Here …

Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy,
chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical …

Confined cell migration hampers genome integrity and activates the ATR and ATM mechano-
transduction pathways. We investigated whether the mechanical stress generated by …