Arachidonate 15-lipoxygenase type B: Regulation, function, and its role in pathophysiology
Y Benatzy, MA Palmer, B Brüne - Frontiers in Pharmacology, 2022 - frontiersin.org
As a lipoxygenase (LOX), arachidonate 15-lipoxygenase type B (ALOX15B) peroxidizes
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
polyenoic fatty acids (PUFAs) including arachidonic acid (AA), eicosapentaenoic acid (EPA) …
Dual COX-2/15-LOX inhibitors: A new avenue in the prevention of cancer
A Aliabadi, E Khanniri, M Mahboubi-Rabbani… - European journal of …, 2023 - Elsevier
Abstract Dual cyclooxygenase 2/15-lipoxygenase inhibitors constitute a valuable alternative
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
to classical non-steroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 …
Antiinflammatory Medicinal Plants from the Ugandan Greater Mpigi Region Act as Potent Inhibitors in the COX-2/PGH2 Pathway
Our study investigates 16 medicinal plants via assessment of inhibition of proinflammatory
enzymes such as cyclooxygenases (COX). The plants are used by traditional healers in the …
enzymes such as cyclooxygenases (COX). The plants are used by traditional healers in the …
15-lipoxygenase and cyclooxygenase expression profile and their related modulators in COVID-19 infection
S Kianfar, V Salimi, A Jahangirifard, SB Mirtajani… - … and Essential Fatty …, 2023 - Elsevier
Background The role of the lipoxygenase (LOX) and cyclooxygenase (COX) enzymes in
maintaining cellular homeostasis and regulating immune responses promoted us in this …
maintaining cellular homeostasis and regulating immune responses promoted us in this …
Identification of novel human 15-lipoxygenase-2 (h15-LOX-2) inhibitors using a virtual screening approach
LG Viviani, TS Iijima, E Piccirillo… - Journal of Medicinal …, 2024 - ACS Publications
The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio-and stereospecific
oxygenation of arachidonate to its corresponding hydroperoxide (15 (S)-HpETE). h15-LOX-2 …
oxygenation of arachidonate to its corresponding hydroperoxide (15 (S)-HpETE). h15-LOX-2 …
[HTML][HTML] Evaluating the expression pattern of the opioid receptor in pituitary neuroendocrine tumors (PitNET) and the role of morphine and naloxone in the regulation …
SF Taghavi, Z Shahsavari, F Adjaminezhad-Fard… - Biomedicine & …, 2023 - Elsevier
Purpose The expression pattern of the opioid receptor (MOR) in pituitary neuroendocrine
tumors (PitNET) and the possible effect of morphine and naloxone on GH3 cell growth and …
tumors (PitNET) and the possible effect of morphine and naloxone on GH3 cell growth and …
Evaluation of the expression of necroptosis pathway mediators and its association with tumor characteristics in functional and non-functional pituitary adenomas
ME Khamseh, A Sheikhi, Z Shahsavari… - BMC endocrine …, 2022 - Springer
Background Pituitary adenomas impose a burden of morbidity on patients and
characterizing the molecular mechanisms underlying its pathogenesis received remarkable …
characterizing the molecular mechanisms underlying its pathogenesis received remarkable …
Cyclooxygenase enzyme and PGE2 expression in patients with functional and non-functional pituitary adenomas
N Akbari, M Ghorbani, V Salimi… - BMC Endocrine …, 2020 - Springer
Background Pituitary adenomas as multifactorial intracranial neoplasms impose a massive
burden of morbidity on patients and characterizing the molecular mechanism underlying …
burden of morbidity on patients and characterizing the molecular mechanism underlying …
Silencing of a Pseudo‐nitzschia arenysensis lipoxygenase transcript leads to reduced oxylipin production and impaired growth
Because of their importance as chemical mediators, the presence of a rich and varied family
of lipoxygenase (LOX) products, collectively named oxylipins, has been investigated …
of lipoxygenase (LOX) products, collectively named oxylipins, has been investigated …
Lipoxygenases at the Intersection of Infection and Carcinogenesis
AS Amoah, NB Pestov, TV Korneenko… - International Journal of …, 2024 - mdpi.com
The persisting presence of opportunistic pathogens like Pseudomonas aeruginosa poses a
significant threat to many immunocompromised cancer patients with pulmonary infections …
significant threat to many immunocompromised cancer patients with pulmonary infections …