The tetrahydroisoquinoline (THIQ) natural products constitute one of the largest families of
alkaloids and exhibit a wide range of structural diversity and biological activity. Ranging from …

Marine secondary metabolites are a promising source of unexploited drugs that have a wide
structural diversity and have shown a variety of biological activities. These compounds are …

The marine environment has proven to be a very rich source of extremely potent compounds
that have demonstrated significant activities in antitumor, antiinflammatory, analgesia …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

Covering: 2003. Previous review: Nat. Prod. Rep., 2004, 21, 1 This review covers the
literature published in 2003 for marine natural products, with 619 citations (413 for the …

The marine environment has proven to be a very rich source of extremely potent compounds
that have demonstrated significant activities in anti-tumor, anti-inflammatory, analgesia …

BACKGROUND AND PURPOSE PM01183 is a new synthetic tetrahydroisoquinoline
alkaloid that is currently in phase I clinical development for the treatment of solid tumours. In …

Marine sponges often house small-molecule-producing symbionts extracellularly in their
mesohyl, providing the host with a means of chemical defence against predation and …

Marine sponges (porifera) have proved to be a prolific source of unique bioactive secondary
metabolites, among which the alkaloids occupy a special place in terms of unprecedented …

Nitrogen-containing heterocyclic compounds are an important class of molecules that are
commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5 …