From real‐world patient data to individualized treatment effects using machine learning: current and future methods to address underlying challenges

I Bica, AM Alaa, C Lambert… - Clinical Pharmacology …, 2021 - Wiley Online Library
Clinical decision making needs to be supported by evidence that treatments are beneficial to
individual patients. Although randomized control trials (RCTs) are the gold standard for …

Causal transformer for estimating counterfactual outcomes

V Melnychuk, D Frauen… - … Conference on Machine …, 2022 - proceedings.mlr.press
Estimating counterfactual outcomes over time from observational data is relevant for many
applications (eg, personalized medicine). Yet, state-of-the-art methods build upon simple …

Recent updates on innovative approaches to overcome drug resistance for better outcomes in cancer

M Sharma, AK Bakshi, N Mittapelly, S Gautam… - Journal of Controlled …, 2022 - Elsevier
The multi-dimensional challenge of drug resistance is one of the pivotal hindrances for
cancer chemotherapy. A reductive approach to define and distinguish the main aspects of …

Forecasting treatment responses over time using recurrent marginal structural networks

B Lim - Advances in neural information processing systems, 2018 - proceedings.neurips.cc
Electronic health records provide a rich source of data for machine learning methods to
learn dynamic treatment responses over time. However, any direct estimation is hampered …

Continuous-time modeling of counterfactual outcomes using neural controlled differential equations

N Seedat, F Imrie, A Bellot, Z Qian… - arXiv preprint arXiv …, 2022 - arxiv.org
Estimating counterfactual outcomes over time has the potential to unlock personalized
healthcare by assisting decision-makers to answer''what-iF''questions. Existing causal …

Active observing in continuous-time control

S Holt, A Hüyük… - Advances in Neural …, 2024 - proceedings.neurips.cc
The control of continuous-time environments while actively deciding when to take costly
observations in time is a crucial yet unexplored problem, particularly relevant to real-world …

Time series deconfounder: Estimating treatment effects over time in the presence of hidden confounders

I Bica, A Alaa… - … conference on machine …, 2020 - proceedings.mlr.press
The estimation of treatment effects is a pervasive problem in medicine. Existing methods for
estimating treatment effects from longitudinal observational data assume that there are no …

Accounting for informative sampling when learning to forecast treatment outcomes over time

T Vanderschueren, A Curth… - International …, 2023 - proceedings.mlr.press
Abstract Machine learning (ML) holds great potential for accurately forecasting treatment
outcomes over time, which could ultimately enable the adoption of more individualized …

G-net: a recurrent network approach to g-computation for counterfactual prediction under a dynamic treatment regime

R Li, S Hu, M Lu, Y Utsumi… - … Learning for Health, 2021 - proceedings.mlr.press
Counterfactual prediction is a fundamental task in decision-making. This paper introduces G-
Net, a sequential deep learning framework for counterfactual prediction under dynamic time …

Bayesian neural controlled differential equations for treatment effect estimation

K Hess, V Melnychuk, D Frauen… - arXiv preprint arXiv …, 2023 - arxiv.org
Treatment effect estimation in continuous time is crucial for personalized medicine.
However, existing methods for this task are limited to point estimates of the potential …