Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Healthy mitochondrial function is imperative for most tissues, but especially those with a high
energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular …

Mitochondrial dysfunction arises from an inadequate number of mitochondria, an inability to
provide necessary substrates to mitochondria, or a dysfunction in their electron transport and …

Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by
chronic exposure to silica dust. In this review, we have proposed that programmed cell death …

Silicon dioxide (SiO2) is a mineral compound present in the Earth's crust in two mineral
forms: crystalline and amorphous. Based on epidemiological and/or biological evidence, the …

The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse
structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various …

Silicosis caused by long-term inhalation of crystalline silica during occupational activities
seriously threatens the health of occupational populations. Imbalances in T helper 1 (Th1) …

Silicosis is a devastating interstitial lung disease arising from long-term exposure to
inhalable silica. Regrettably, no therapy currently can effectively reverse the silica-induced …

Silicosis is one of the most severe occupational diseases worldwide and is characterized by
silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are …