Loss of protein homeostasis (proteostasis) is a common feature of aging and disease that is
characterized by the appearance of nonnative protein aggregates in various tissues. Protein …

Huntington's disease (HD) is a progressive neurodegenerative disorder for which no
disease modifying treatments exist. Many molecular changes and cellular consequences …

The heat shock response (HSR) is essential for proteostasis and cellular health. In
metazoans, aging is associated with a decline in quality control, thus increasing the risk for …

The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …

Throughout the genome, unstable tandem nucleotide repeats can expand to cause a variety
of neurologic disorders. Expansion of a CAG triplet repeat within a coding exon gives rise to …

Protein misfolding and aggregation are a hallmark of several neurodegenerative diseases
(ND s). However, how protein aggregation leads to cytotoxicity and neurodegeneration is …

Although protein-misfolding-mediated neurodegenerative diseases have been linked to
aging, how aging contributes to selective neurodegeneration remains unclear. We …

Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder with progressive
degeneration of cerebellar Purkinje cells (PCs) and other neurons caused by expansion of a …

Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is a
neurodegenerative disease currently with no treatment. We describe a novel mouse model …

NF-Y is a conserved sequence-specific trimeric Transcription Factor-TF-binding to the
CCAAT element. We review here the role (s) in development, from pre-implantation embryo …