Regulation by 3′-untranslated regions

C Mayr - Annual review of genetics, 2017 - annualreviews.org
3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …

[HTML][HTML] lincRNAs: genomics, evolution, and mechanisms

I Ulitsky, DP Bartel - Cell, 2013 - cell.com
Long intervening noncoding RNAs (lincRNAs) are transcribed from thousands of loci in
mammalian genomes and might play widespread roles in gene regulation and other cellular …

Thoughts on how to think (and talk) about RNA structure

Q Vicens, JS Kieft - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …

Structure and function of long noncoding RNAs in epigenetic regulation

TR Mercer, JS Mattick - Nature structural & molecular biology, 2013 - nature.com
Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

MicroRNA targeting specificity in mammals: determinants beyond seed pairing

A Grimson, KKH Farh, WK Johnston, P Garrett-Engele… - Molecular cell, 2007 - cell.com
Mammalian microRNAs (miRNAs) pair to 3′ UTRs of mRNAs to direct their
posttranscriptional repression. Important for target recognition are∼ 7 nt sites that match the …

Functional complexity and regulation through RNA dynamics

EA Dethoff, J Chugh, AM Mustoe, HM Al-Hashimi - Nature, 2012 - nature.com
Abstract Changes to the conformation of coding and non-coding RNAs form the basis of
elements of genetic regulation and provide an important source of complexity, which drives …

Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions

F Bonneau, J Basquin, B Steigenberger… - Genes & …, 2023 - genesdev.cshlp.org
Messenger RNAs (mRNAs) are at the center of the central dogma of molecular biology. In
eukaryotic cells, these long ribonucleic acid polymers do not exist as naked transcripts; …

Analysis of non‐coding transcriptome in rice and maize uncovers roles of conserved lnc RNA s associated with agriculture traits

H Wang, QW Niu, HW Wu, J Liu, J Ye, N Yu… - The Plant …, 2015 - Wiley Online Library
Long non‐coding RNA s (lnc RNA s) have recently been found to widely exist in eukaryotes
and play important roles in key biological processes. To extend our knowledge of lnc RNA s …

Genome-wide measurement of RNA folding energies

Y Wan, K Qu, Z Ouyang, M Kertesz, J Li, R Tibshirani… - Molecular cell, 2012 - cell.com
RNA structural transitions are important in the function and regulation of RNAs. Here, we
reveal a layer of transcriptome organization in the form of RNA folding energies. By probing …

Observation of coordinated RNA folding events by systematic cotranscriptional RNA structure probing

CE Szyjka, EJ Strobel - Nature Communications, 2023 - nature.com
RNA begins to fold as it is transcribed by an RNA polymerase. Consequently, RNA folding is
constrained by the direction and rate of transcription. Understanding how RNA folds into …