Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes

RM Kini - Toxicon, 2003 - Elsevier
Venom phospholipase A2 (PLA2) enzymes share similarity in structure and catalytic function
with mammalian enzymes. However, in contrast to mammalian enzymes, many are toxic and …

Auxiliary subunits of voltage-gated ion channels

LL Isom, KS De Jongh, WA Catterall - Neuron, 1994 - Elsevier
The voltage-gated Na+, Ca*+, and K+ channels are responsible for the generation of action
potentials in neurons and other excitable cells. These channels are also involved in cellular …

[图书][B] Polysaccharides: structural diversity and functional versatility

S Dumitriu - 2004 - taylorfrancis.com
Completely revised and expanded to reflect the latest advancements in the field,
Polysaccharides: Structural Diversity and Functional Versatility, Second Edition outlines …

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

J Rettig, SH Heinemann, F Wunder, C Lorra, DN Parcej… - Nature, 1994 - nature.com
Structural and functional diversity of voltage-gated Kv1-type potassium channels in rat brain
is enhanced by the association of two different types of subunits, the membrane-bound, pore …

Ancillary Subunits Associated With Voltage-Dependent K+ Channels

O Pongs, JR Schwarz - Physiological reviews, 2010 - journals.physiology.org
Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

Ophidian envenomation strategies and the role of purines

SD Aird - Toxicon, 2002 - Elsevier
Snake envenomation employs three well integrated strategies: prey immobilization via
hypotension, prey immobilization via paralysis, and prey digestion. Purines (adenosine …

[HTML][HTML] βSubunits promote K+ channel surface expression through effects early in biosynthesis

G Shi, K Nakahira, S Hammond, KJ Rhodes… - Neuron, 1996 - cell.com
Voltage-gated K+ channels are protein complexes composed of ion-conducting integral
membrane α subunits and cytoplasmic β subunits. Here, we show that, in transfected …

Twenty years of dendrotoxins

AL Harvey - Toxicon, 2001 - Elsevier
Dendrotoxins are small proteins that were isolated 20 years ago from mamba (Dendroaspis)
snake venoms (Harvey, AL, Karlsson, E., 1980. Dendrotoxin from the venom of the green …

[HTML][HTML] Primary sequence and immunological characterization of beta-subunit of high conductance Ca (2+)-activated K+ channel from smooth muscle.

HG Knaus, K Folander, M Garcia-Calvo… - Journal of Biological …, 1994 - Elsevier
The charybdotoxin receptor, purified from bovine tracheal smooth muscle, consists of two
subunits (alpha and beta) and, when reconstituted into planar lipid bilayers, forms functional …

Structure–function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms

RM Kini - Toxicon, 2005 - Elsevier
Phospholipase A2 (PLA2) enzymes from snake venom are toxic and induce a wide
spectrum of pharmacological effects, despite similarity in primary, secondary and tertiary …