The interplay between chromatin, transcription factors and genes generates complex
regulatory circuits that can be represented as gene regulatory networks (GRNs). The study …

Summary Although the Bacille-Calmette-Guérin (BCG) vaccine is used to prevent
tuberculosis, it also offers protection against a diverse range of non-mycobacterial infections …

Super‐enhancers (SEs) have been recognized as key epigenetic regulators underlying
cancer stemness and malignant traits by aberrant transcriptional control and promising …

Metabolic-epigenetic interactions are emerging as key pathways in regulating alcohol-
related transcriptional changes in the brain. Recently, we have shown that this is mediated …

Background Understanding the functional impact of genetic variants is essential for
advancing animal genomics and improving livestock breeding. Variants that disrupt …

Abstract The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators
of nucleosomal remodeling that are commonly mutated in several cancers, including …

This study investigates the impact of maternal gestation diets with varying fiber contents on
gene expression and chromatin accessibility in fetuses and piglets fed a low fiber diet post …

Heart failure is caused in part by cardiac remodeling processes that include the death of
cardiac myocytes and their replacement by cardiac fibroblasts. We hypothesized that these …

Motivation Enhancers play critical roles in cell-type-specific transcriptional control. Despite
the identification of thousands of candidate enhancers, unravelling their regulatory …