Microtubules are cytoskeletal components involved in pivotal eukaryotic functions such as
cell division, ciliogenesis, and intracellular trafficking. They assemble from αβ-tubulin …

In textbooks, the mitotic spindles of plants are often described separately from those of
animals. How do they differ at the molecular and mechanistic levels? In this chapter, we first …

Background The dynamic properties of microtubules depend on complex nanoscale
structural rearrangements in their end regions. Members of the EB1 and XMAP215 protein …

Error-free cell division depends on the assembly of the spindle midzone, a specialized array
of overlapping microtubules that emerges between segregating chromosomes during …

The function of microtubules relies on their ability to switch between phases of growth and
shrinkage. A nucleotide-dependent stabilising cap at microtubule ends is thought to be lost …

Microtubules (MTs) are highly conserved polar polymers that are key elements of the
eukaryotic cytoskeleton and are essential for various cell functions. αβ-tubulin, a …

Growing microtubule end regions recruit a variety of proteins collectively termed+ TIPs,
which confer local functions to the microtubule cytoskeleton.+ TIPs form dynamic interaction …

Microtubules are hollow, cylindrical polymers of the protein α, β tubulin, that interact
mechanochemically with a variety of macromolecules. Due to their mechanically robust …

Tubulin folding cofactors (TFCs) are required for tubulin folding, α/β tubulin heterodimer
formation, and microtubule (MT) dynamics in yeast and mammals. However, the functions of …

The mitotic kinase Aurora B is concentrated at the anaphase central spindle by the kinesin
MKlp2 during mitotic exit and cytokinesis. This pool of Aurora B phosphorylates substrates …