Therapeutic potential of phosphodiesterase inhibitors against neurodegeneration: The perspective of the medicinal chemist
Increasing human life expectancy prompts the development of novel remedies for cognitive
decline: 44 million people worldwide are affected by dementia, and this number is predicted …
decline: 44 million people worldwide are affected by dementia, and this number is predicted …
Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling …
Drug abuse changes neurophysiological functions at multiple cellular and molecular levels
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …
in the addicted brain. Well-supported scientific evidence suggests that drugs negatively …
A copper (II) phthalocyanine-based metallo-covalent organic framework decorated with silver nanoparticle for sensitively detecting nitric oxide released from cancer …
M Wang, L Zhu, S Zhang, Y Lou, S Zhao, Q Tan… - Sensors and Actuators B …, 2021 - Elsevier
A novel metallo-copper phthalocyanine-based covalent-organic framework (CuTAPc-MCOF)
doped with silver nanoparticles (denoted as CuTAPc-MCOF@ AgNPs) was developed …
doped with silver nanoparticles (denoted as CuTAPc-MCOF@ AgNPs) was developed …
Targeting neuronal nitric oxide synthase and the nitrergic system in post-traumatic stress disorder
Rationale Current pharmacological approaches to treatment of post-traumatic stress
disorder (PTSD) lack adequate effectiveness. As a result, identifying new molecular targets …
disorder (PTSD) lack adequate effectiveness. As a result, identifying new molecular targets …
Activation of VTA/CeA/mPFC cannabinoid CB1 receptors induced conditioned drug effects via interacting with hippocampal CAMKII-CREB-BDNF signaling pathway in …
The present study intended to investigate whether the activation of cannabinoid CB1
receptors of the ventral tegmental area (VTA), the central amygdala (CeA) and the medial …
receptors of the ventral tegmental area (VTA), the central amygdala (CeA) and the medial …
The role of glutamate NMDA receptors of the mediodorsal thalamus in scopolamine-induced amnesia in rats
MV Khesmakhi, Z Salimi, A Pourmotabbed… - Neuroscience …, 2024 - Elsevier
The current study was designed to examine the role of glutamate NMDA receptors of the
mediodorsal thalamus (MD) in scopolamine-induced memory impairment. Adult male rats …
mediodorsal thalamus (MD) in scopolamine-induced memory impairment. Adult male rats …
Pharmacological activation of mediodorsal thalamic GABA-A receptors modulates morphine/cetirizine-induced changes in the prefrontal cortical GFAP expression in a …
N Asgharpour-Masouleh, A Rezayof… - Behavioural Brain …, 2023 - Elsevier
The present study investigated the involvement of mediodorsal thalamic (MD) GABA-A
receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic …
receptors in cetirizine/morphine-induced anti-allodynia using a rat model of neuropathic …
γ‐Oryzanol Ameliorates Depressive Behavior in Ovariectomized Mice by Regulating Hippocampal Nitric Oxide Synthase: A Potential Therapy for Menopausal …
M Kim, M Yoon, S Cho, C Lee… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Depression is a severe mental condition, common among menopausal women. γ‐
Oryzanol (ORY) has various biological properties; however, the effect of ORY on …
Oryzanol (ORY) has various biological properties; however, the effect of ORY on …
Expression analysis of hippocampal and amygdala CREB-BDNF signaling pathway in nicotine-induced reward under stress in rats
Extensive research has shown that individuals are more sensitive to develop addiction and
drug taking under stress state. The present study includes an expression analysis to identify …
drug taking under stress state. The present study includes an expression analysis to identify …
Activation of mediodorsal thalamic dopamine receptors inhibited nicotine-induced anxiety in rats: A possible role of corticolimbic NMDA neurotransmission and BDNF …
The present study aimed to evaluate the functional interaction between the dopaminergic
and glutamatergic systems of the mediodorsal thalamus (MD), the ventral hippocampus …
and glutamatergic systems of the mediodorsal thalamus (MD), the ventral hippocampus …