Hyperprolactinaemia is one of the most common problems in clinical endocrinology. It
relates with various aetiologies (physiological, pharmacological, pathological), the …

Prolactin is a polypeptide hormone that is synthesized in the anterior pituitary gland and
secreted in a pulsatile manner. It plays central role in a variety of reproductive functions and …

Over the last years, the metabolic role of PRL has emerged. PRL excess is known to
promote weight gain, obesity, metabolic syndrome, and impairment in gluco-insulinemic and …

Abstract [Despite as a major inhibitor of urokinase (uPA), paradoxically,] Plasminogen
activator inhibitor-1 (PAI-1) has been validated to be highly expressed in various types of …

Bromocriptine is a sympatholytic dopamine D2 receptor agonist with remarkable
bioactivities. It has been used clinically as a prescription drug for more than 30 years to treat …

Hyperprolactinemia has been associated with impaired metabolism, including insulin
resistance. However, the metabolic effects of elevated prolactin (PRL) levels are not …

The fall of PRL levels below the lower limit of the normal range configures the condition of
hypoprolactinemia. Unlike PRL excess, whose clinical features and treatments are well …

Aims Increased serum prolactin (PRL) concentrations have been associated with adverse
cardiovascular risk profiles, but the relation between PRL and mortality risk is unknown …

Prolactin, a hormone that has been studied for almost a century, has evolved from a
reproductive regulator to a key player in metabolic health. Initially identified for its lactogenic …

Hyperprolactinemia can be caused by several conditions and its effects on the hypothalamic-
pituitary-gonadal axis are understood in more detail. Nevertheless, in recent decades, other …