The development of synthetic chemistry since the early 1900s owes much to the service of
organolithium reagents. Brilliant bases (eg, deprotonating C–H bonds), nucleophiles (eg …

Many contemporary organic transformations, such as Ni-catalyzed cross-electrophile
coupling (XEC), require a reductant. Typically, heterogeneous reductants, such as Zn0 or …

Alkyl chlorides and aryl chlorides are among the most abundant and stable carbon
electrophiles. Although their coupling with carbon nucleophiles is well developed, the cross …

While the synthesis of biaryls has advanced rapidly in the past decades, cross-Ullman
couplings of aryl chlorides, the most abundant aryl electrophiles, have remained elusive …

Historically accessed through two-electron, anionic chemistry, ketones, alcohols, and
amines are of foundational importance to the practice of organic synthesis. After placing this …

This work illustrates the reductive coupling of electron-rich aryl halides with tertiary alkyl
halides under Ni-catalyzed cross-electrophile coupling conditions, which offers an efficient …

Zn-mediated reduction of readily accessible dialkyl oxalates derived from tertiary alcohols
provides an efficient approach to C–O bond fragmentation and alkyl radical formation. With …

Direct coupling of unactivated alcohols remains a challenge in current synthetic chemistry.
We herein demonstrate a strategy building upon in situ halogenation/reductive coupling of …

Optical super-resolution imaging has gained momentum in investigations of heterogeneous
and homogeneous chemical reactions at the single-molecule level. Thanks to its exceptional …

A new method for the synthesis of terminal and internal alkynes from the nickel‐catalyzed
decarboxylative coupling of N‐hydroxyphthalimide esters and bromoalkynes is presented …