Simple Summary Glioblastoma multiforme (GBM) is one of the most aggressive
malignancies, accounting for 14.5% of all central nervous system tumors and 48.6% of …

The p53 protein is a transcription factor known as the" guardian of the genome" because of
its critical function in preserving genomic integrity. The TP53 gene is mutated in …

Forty years of research have established that the p53 tumor suppressor provides a major
barrier to neoplastic transformation and tumor progression by its unique ability to act as an …

Cell adhesion to the extracellular matrix is fundamental to tissue integrity and human health.
Integrins are the main cellular adhesion receptors that through multifaceted roles as …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Abstract p53 is a key tumor suppressor, and loss of p53 function is frequently a prerequisite
for cancer development. The p53 gene is the most frequently mutated gene in human …

TP53 is the most frequently mutated tumor suppressor gene in human cancer. The majority
of mutations of p53 are missense mutations, leading to the expression of the full length p53 …

Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

Mutations in the TP53 tumour suppressor gene are found in~ 50% of human cancers [,,,,–].
TP53 functions as a transcription factor that directly regulates the expression of~ 500 genes …