Metastasis is the leading cause of cancer-related mortality; however, a complete
understanding of the molecular programs driving the metastatic cascade is lacking …

Many solid tumors exhibit significant genetic, cellular, and biophysical heterogeneity which
dynamically evolves during disease progression and after treatment. This constant flux in …

Intra-tumor heterogeneity, ie, the presence of diverse cell types and subpopulations within
tumors, presents a significant obstacle in cancer treatment due to its negative consequences …

Drug resistance is always a challenge in cancer treatment, whether for chemotherapy,
targeting, or immunotherapy. Although tumor cell lines are derived from cancer patients, they …

Ductal carcinoma in situ (DCIS) is a noninvasive breast disease that variably progresses to
invasive breast cancer (IBC). Given the unpredictability of this progression, most DCIS …

Non-small cell lung cancer (NSCLC) collective invasion is supported by cooperativity of
proliferative (follower) and invasive (leader) cells. H1299-isolated follower cells exhibit …

Collagen is a crucial protein in the extracellular matrix (ECM) essential for preserving tissue
architecture and supporting crucial cellular functions like proliferation and differentiation …

Abstract Yes-associated protein (YAP), the key transcriptional co-factor and downstream
effector of the Hippo pathway, has emerged as one of the primary regulators of neural as …

Background Tumor-infiltrating regulatory T cells (TI-Tregs) are well-adapted to thrive in the
challenging tumor microenvironment (TME) by undergoing metabolic reprogramming …

G protein-coupled receptors (GPCRs) are the largest class of membrane-bound receptors
and transmit critical signals from the extracellular to the intracellular spaces. Transcriptomic …